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The structure from the unliganded double mutant HIV-1 RT showed that Lys103Asn mutation facilitates coordination of a sodium ion with Lys101 O, Asn103 N and O(delta1), Tyr188 O(eta), and two drinking water molecules. The development of the binding pocket calls for the removing from the sodium ion. Even though the RT alone plus the RT/HBY 097 compli

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